Assay Detail
Binding
CHEMBL4482786
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Inhibition of IDO1 (unknown origin) using L-tryptophan as substrate assessed as reduction in conversion of N-formyl kynurenine to kynurenine
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.63 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432537 | — | — | 1 | 6.99 |
| CHEMBL1098875 | — | — | 1 | 6.27 |
| CHEMBL72165 | — | — | 1 | 6.24 |
| CHEMBL3087009 | — | — | 1 | 5.57 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 5.15 |
| CHEMBL3087010 | — | — | 1 | 5.09 |
| CHEMBL1276265 | — | — | 1 | 4.13 |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | — | 1 | - |
| CHEMBL571209 | INDOXIMOD | 2.0 | 1 | - |
| CHEMBL312537 | — | — | 1 | - |
| CHEMBL3086870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432537 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL1098875 | — | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL72165 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL3087009 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL306946 | TRYPTANTHRIN | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL3087010 | — | IC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL1276265 | — | IC50 | = | 74370.0 | nM | 4.13 |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | IC50 | = | 380000.0 | nM | - |
| CHEMBL571209 | INDOXIMOD | IC50 | - | — | - | |
| CHEMBL312537 | — | IC50 | = | 121200.0 | nM | - |
| CHEMBL3086870 | — | IC50 | = | 864400.0 | nM | - |