Assay Detail
Binding
CHEMBL4482789
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in human U87MG cells in presence of L-tryptophan incubated for 24 h
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.94 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276265 | — | — | 1 | 6.74 |
| CHEMBL3087009 | — | — | 1 | 6.33 |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | — | 1 | 4.74 |
| CHEMBL571209 | INDOXIMOD | 2.0 | 1 | - |
| CHEMBL312537 | — | — | 1 | - |
| CHEMBL1098875 | — | — | 1 | - |
| CHEMBL72165 | — | — | 1 | - |
| CHEMBL3086870 | — | — | 1 | - |
| CHEMBL3087010 | — | — | 1 | - |
| CHEMBL432537 | — | — | 1 | - |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276265 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3087009 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL571209 | INDOXIMOD | IC50 | - | — | - | |
| CHEMBL312537 | — | IC50 | > | 3900000.0 | nM | - |
| CHEMBL1098875 | — | IC50 | = | 23000000.0 | nM | - |
| CHEMBL72165 | — | IC50 | = | 53900000.0 | nM | - |
| CHEMBL3086870 | — | IC50 | > | 3900000.0 | nM | - |
| CHEMBL3087010 | — | IC50 | = | 27100000.0 | nM | - |
| CHEMBL432537 | — | IC50 | = | 18000.0 | nM | - |
| CHEMBL306946 | TRYPTANTHRIN | IC50 | = | 53700000.0 | nM | - |