Assay Detail
Binding
CHEMBL4482790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO2 (unknown origin) expressed in human U87MG cells in presence of L-tryptophan incubated for 24 h
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.08 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432537 | — | — | 1 | 6.35 |
| CHEMBL1098875 | — | — | 1 | 5.91 |
| CHEMBL72165 | — | — | 1 | 5.49 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 5.30 |
| CHEMBL3087009 | — | — | 1 | 5.09 |
| CHEMBL1276265 | — | — | 1 | 4.74 |
| CHEMBL3087010 | — | — | 1 | 4.71 |
| CHEMBL312537 | — | — | 1 | 4.66 |
| CHEMBL3086870 | — | — | 1 | 4.42 |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | — | 1 | 4.08 |
| CHEMBL571209 | INDOXIMOD | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432537 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL1098875 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL72165 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL306946 | TRYPTANTHRIN | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL3087009 | — | IC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL1276265 | — | IC50 | = | 18370.0 | nM | 4.74 |
| CHEMBL3087010 | — | IC50 | = | 19450.0 | nM | 4.71 |
| CHEMBL312537 | — | IC50 | = | 21810.0 | nM | 4.66 |
| CHEMBL3086870 | — | IC50 | = | 37780.0 | nM | 4.42 |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | IC50 | = | 82530.0 | nM | 4.08 |
| CHEMBL571209 | INDOXIMOD | IC50 | = | 148900.0 | nM | - |