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Assay Detail

CHEMBL4482791

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of SAE (unknown origin) using recombinant His-tagged human SUMO1 measured after 2 hrs by HTRF assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

SUMO-activating enzyme (CHEMBL2095174)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Novel heterocyclic compound, method for preparing same, and pharmaceutical composition comprising same as active ingredient for preventing or treating cancer
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.12 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4585101 1 7.52
CHEMBL4521457 1 7.40
CHEMBL4576812 1 7.00
CHEMBL4577730 1 6.92
CHEMBL4566409 1 6.34
CHEMBL4592057 1 6.33
CHEMBL4582044 1 6.28
CHEMBL4569826 1 6.25
CHEMBL4567852 1 6.18
CHEMBL4515314 1 6.17
CHEMBL4546722 1 6.00
CHEMBL4530438 1 5.89
CHEMBL4591942 1 5.80
CHEMBL4571260 1 5.78
CHEMBL4537144 1 5.78
CHEMBL4564365 1 5.77
CHEMBL4558498 1 5.76
CHEMBL4588670 1 5.74
CHEMBL4589876 1 5.73
CHEMBL4585904 1 5.66
CHEMBL4547326 1 5.54
CHEMBL4514025 1 5.50
CHEMBL4570552 1 5.46
CHEMBL4580824 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4585101 IC50 = 30.0 nM 7.52
CHEMBL4521457 IC50 = 40.0 nM 7.40
CHEMBL4576812 IC50 = 100.0 nM 7.00
CHEMBL4577730 IC50 = 120.0 nM 6.92
CHEMBL4566409 IC50 = 460.0 nM 6.34
CHEMBL4592057 IC50 = 470.0 nM 6.33
CHEMBL4582044 IC50 = 530.0 nM 6.28
CHEMBL4569826 IC50 = 560.0 nM 6.25
CHEMBL4567852 IC50 = 661.0 nM 6.18
CHEMBL4515314 IC50 = 680.0 nM 6.17
CHEMBL4546722 IC50 = 990.0 nM 6.00
CHEMBL4530438 IC50 = 1290.0 nM 5.89
CHEMBL4591942 IC50 = 1600.0 nM 5.80
CHEMBL4571260 IC50 = 1650.0 nM 5.78
CHEMBL4537144 IC50 = 1650.0 nM 5.78
CHEMBL4564365 IC50 = 1700.0 nM 5.77
CHEMBL4558498 IC50 = 1720.0 nM 5.76
CHEMBL4588670 IC50 = 1840.0 nM 5.74
CHEMBL4589876 IC50 = 1860.0 nM 5.73
CHEMBL4585904 IC50 = 2210.0 nM 5.66
CHEMBL4547326 IC50 = 2880.0 nM 5.54
CHEMBL4514025 IC50 = 3180.0 nM 5.50
CHEMBL4570552 IC50 = 3480.0 nM 5.46
CHEMBL4580824 IC50 > 10000.0 nM -