Assay Detail
Binding
CHEMBL4602773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV NS3/4a protease using Ac-DE-Dap(QXL520)-EE-Abu-shi-[COO]AS-C(5-FAMsp)-NH2 as substrate after 15 mins
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
A review on HCV inhibitors: Significance of non-structural polyproteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.97 | 9.70 |
| Ki | 1 | 8.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 9.70 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 8.70 |
| CHEMBL4287268 | — | — | 1 | 8.52 |
| CHEMBL1255891 | NARLAPREVIR | 3.0 | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4287268 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1255891 | NARLAPREVIR | Ki | = | 6.0 | nM | 8.22 |