Assay Detail
Binding
CHEMBL4602779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to HCV NS5B polymerase
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
A review on HCV inhibitors: Significance of non-structural polyproteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.55 | 7.72 |
| Kd | 3 | 5.96 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353549 | — | — | 1 | 7.72 |
| CHEMBL223720 | — | — | 1 | 6.14 |
| CHEMBL175177 | — | — | 1 | 5.80 |
| CHEMBL388502 | — | — | 1 | 5.77 |
| CHEMBL3617579 | — | — | 1 | 5.06 |
| CHEMBL4641216 | — | — | 1 | 4.80 |
| CHEMBL474496 | — | — | 1 | 4.35 |
| CHEMBL427101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353549 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL223720 | — | Kd | = | 720.0 | nM | 6.14 |
| CHEMBL175177 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL388502 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL3617579 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4641216 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL474496 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL427101 | — | Kd | > | 100000.0 | nM | - |