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Assay Detail

CHEMBL4602782

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to HCV NS5A polymerase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Nonstructural protein 5A (CHEMBL3307224)
Type SINGLE PROTEIN
Organism Hepatitis C virus

Publication

A review on HCV inhibitors: Significance of non-structural polyproteins.
Ganta NM, Gedda G, Rathnakar B, Satyanarayana M, Yamajala B, Ahsan MJ, Jadav SS, Balaraju T.
Eur J Med Chem (2019) 164 : 576 -601
PubMed 30639895 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.23 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4638107 1 8.40
CHEMBL4638630 1 8.37
CHEMBL4635161 1 8.22
CHEMBL245328 1 8.14
CHEMBL4643906 1 8.00
CHEMBL4638877 1 8.00
CHEMBL4643189 1 7.77
CHEMBL3422107 1 7.72
CHEMBL480816 1 7.57
CHEMBL390883 1 7.38
CHEMBL213832 1 7.24
CHEMBL1783101 1 7.16
CHEMBL362058 1 6.80
CHEMBL1087567 1 6.52
CHEMBL4633554 1 6.47
CHEMBL217625 1 6.47
CHEMBL182020 1 6.30
CHEMBL4642429 1 6.26
CHEMBL4639473 1 6.22
CHEMBL206461 1 5.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4638107 IC50 = 4.0 nM 8.40
CHEMBL4638630 IC50 = 4.3 nM 8.37
CHEMBL4635161 IC50 = 6.0 nM 8.22
CHEMBL245328 IC50 = 7.2 nM 8.14
CHEMBL4643906 IC50 = 10.0 nM 8.00
CHEMBL4638877 IC50 = 10.0 nM 8.00
CHEMBL4643189 IC50 = 17.0 nM 7.77
CHEMBL3422107 IC50 = 19.0 nM 7.72
CHEMBL480816 IC50 = 27.0 nM 7.57
CHEMBL390883 IC50 = 42.0 nM 7.38
CHEMBL213832 IC50 = 58.0 nM 7.24
CHEMBL1783101 IC50 = 70.0 nM 7.16
CHEMBL362058 IC50 = 160.0 nM 6.80
CHEMBL1087567 IC50 = 300.0 nM 6.52
CHEMBL4633554 IC50 = 340.0 nM 6.47
CHEMBL217625 IC50 = 340.0 nM 6.47
CHEMBL182020 IC50 = 500.0 nM 6.30
CHEMBL4642429 IC50 = 550.0 nM 6.26
CHEMBL4639473 IC50 = 600.0 nM 6.22
CHEMBL206461 IC50 = 3200.0 nM 5.50