Assay Detail
Binding
CHEMBL4603100
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Inhibition of Keap1-Nrf2 Interaction (unknown origin) by fluorescence anisotropy
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.58 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634168 | — | — | 1 | 7.26 |
| CHEMBL4174651 | — | — | 1 | 7.20 |
| CHEMBL4646536 | — | — | 1 | 7.14 |
| CHEMBL4641049 | — | — | 1 | 6.92 |
| CHEMBL4648321 | — | — | 1 | 6.89 |
| CHEMBL4640762 | — | — | 1 | 6.68 |
| CHEMBL4649822 | — | — | 1 | 6.64 |
| CHEMBL4637137 | — | — | 1 | 6.62 |
| CHEMBL4640093 | — | — | 1 | 6.55 |
| CHEMBL4641622 | — | — | 1 | 6.46 |
| CHEMBL4645359 | — | — | 1 | 6.38 |
| CHEMBL4648175 | — | — | 1 | 6.37 |
| CHEMBL4635609 | — | — | 1 | 6.00 |
| CHEMBL4648275 | — | — | 1 | 5.96 |
| CHEMBL4649258 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634168 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4174651 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4646536 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4641049 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4648321 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4640762 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4649822 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4637137 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4640093 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4641622 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4645359 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4648175 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4635609 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4648275 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4649258 | — | IC50 | = | 2300.0 | nM | 5.64 |