Assay Detail
Functional
CHEMBL4603149
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Antiproliferative activity against human MGC803 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
14
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1,2,4-triazine-based derivatives as novel neddylation inhibitors and anticancer activity studies against gastric cancer MGC-803 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.80 | 5.08 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4640167 | — | — | 2 | 5.08 |
| CHEMBL4644473 | — | — | 1 | 5.06 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.01 |
| CHEMBL4648766 | — | — | 1 | 4.95 |
| CHEMBL4645176 | — | — | 1 | 4.90 |
| CHEMBL4640913 | — | — | 1 | 4.89 |
| CHEMBL4638309 | — | — | 1 | 4.82 |
| CHEMBL4638461 | — | — | 1 | 4.78 |
| CHEMBL4643767 | — | — | 1 | 4.72 |
| CHEMBL4648863 | — | — | 1 | 4.70 |
| CHEMBL4639508 | — | — | 1 | 4.61 |
| CHEMBL4633678 | — | — | 1 | 4.55 |
| CHEMBL4645173 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4640167 | — | IC50 | = | 8220.0 | nM | 5.08 |
| CHEMBL4644473 | — | IC50 | = | 8750.0 | nM | 5.06 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 9790.0 | nM | 5.01 |
| CHEMBL4648766 | — | IC50 | = | 11350.0 | nM | 4.95 |
| CHEMBL4645176 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL4640913 | — | IC50 | = | 13010.0 | nM | 4.89 |
| CHEMBL4638309 | — | IC50 | = | 15220.0 | nM | 4.82 |
| CHEMBL4638461 | — | IC50 | = | 16460.0 | nM | 4.78 |
| CHEMBL4643767 | — | IC50 | = | 18950.0 | nM | 4.72 |
| CHEMBL4648863 | — | IC50 | = | 19790.0 | nM | 4.70 |
| CHEMBL4639508 | — | IC50 | = | 24310.0 | nM | 4.61 |
| CHEMBL4633678 | — | IC50 | = | 28130.0 | nM | 4.55 |
| CHEMBL4645173 | — | IC50 | = | 53620.0 | nM | 4.27 |
| CHEMBL4640167 | — | Inhibition | - | % | - |