Assay Detail
Functional
CHEMBL4603150
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Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1,2,4-triazine-based derivatives as novel neddylation inhibitors and anticancer activity studies against gastric cancer MGC-803 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.72 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4648766 | — | — | 1 | 5.05 |
| CHEMBL4640167 | — | — | 1 | 5.03 |
| CHEMBL4645176 | — | — | 1 | 5.02 |
| CHEMBL4644473 | — | — | 1 | 5.01 |
| CHEMBL4638461 | — | — | 1 | 4.95 |
| CHEMBL4643767 | — | — | 1 | 4.87 |
| CHEMBL4648863 | — | — | 1 | 4.85 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.69 |
| CHEMBL4638309 | — | — | 1 | 4.49 |
| CHEMBL4639508 | — | — | 1 | 4.46 |
| CHEMBL4640913 | — | — | 1 | 4.41 |
| CHEMBL4633678 | — | — | 1 | 4.31 |
| CHEMBL4645173 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4648766 | — | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL4640167 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL4645176 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4644473 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL4638461 | — | IC50 | = | 11260.0 | nM | 4.95 |
| CHEMBL4643767 | — | IC50 | = | 13470.0 | nM | 4.87 |
| CHEMBL4648863 | — | IC50 | = | 14260.0 | nM | 4.85 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 20420.0 | nM | 4.69 |
| CHEMBL4638309 | — | IC50 | = | 32150.0 | nM | 4.49 |
| CHEMBL4639508 | — | IC50 | = | 34310.0 | nM | 4.46 |
| CHEMBL4640913 | — | IC50 | = | 38630.0 | nM | 4.41 |
| CHEMBL4633678 | — | IC50 | = | 48480.0 | nM | 4.31 |
| CHEMBL4645173 | — | IC50 | = | 58450.0 | nM | 4.23 |