Assay Detail
Binding
CHEMBL4603183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Aggregation-based inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPH and 0.05% Triton X-100 by detergent-addition assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.23 | 4.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908021 | — | — | 1 | 4.32 |
| CHEMBL4640749 | — | — | 1 | 4.14 |
| CHEMBL1869748 | — | — | 1 | - |
| CHEMBL289046 | — | — | 1 | - |
| CHEMBL4635409 | — | — | 1 | - |
| CHEMBL4648564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908021 | — | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL4640749 | — | IC50 | = | 71900.0 | nM | 4.14 |
| CHEMBL1869748 | — | IC50 | = | 319000.0 | nM | - |
| CHEMBL289046 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL4635409 | — | IC50 | = | 453000.0 | nM | - |
| CHEMBL4648564 | — | IC50 | = | 433000.0 | nM | - |