Assay Detail
Binding
CHEMBL4603186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-perturbation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.05 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 7.37 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 6.82 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.80 |
| CHEMBL1908021 | — | — | 1 | 4.19 |
| CHEMBL4640749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 42.8 | nM | 7.37 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL266497 | SORBINIL | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL1908021 | — | IC50 | = | 64200.0 | nM | 4.19 |
| CHEMBL4640749 | — | IC50 | = | 178000.0 | nM | - |