Assay Detail
Binding
CHEMBL4603187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKR1B10 (unknown origin) pretreated with 0.25M DMSO followed by compound treatment by DMSO-perturbation assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B10 (CHEMBL5983) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.45 | 7.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 35.2 | nM | 7.45 |