Assay Detail
Binding
CHEMBL4603663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse 11beta-HSD1 expressed in CHOK1 cells using XL665-labeled cortisol as substrate measured after 24 hrs by HTRF assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Optimization of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.36 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3951168 | — | — | 1 | 9.00 |
| CHEMBL4633146 | — | — | 1 | 9.00 |
| CHEMBL4645319 | — | — | 1 | 9.00 |
| CHEMBL3663671 | — | — | 1 | 8.70 |
| CHEMBL4648389 | — | — | 1 | 8.43 |
| CHEMBL4646414 | — | — | 1 | 7.17 |
| CHEMBL4638272 | — | — | 1 | 6.76 |
| CHEMBL499915 | CARBENOXOLONE | 2.0 | 1 | 6.61 |
| CHEMBL4638268 | — | — | 1 | 6.16 |
| CHEMBL4649416 | — | — | 1 | 6.03 |
| CHEMBL4632806 | — | — | 1 | 5.92 |
| CHEMBL4647977 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3951168 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4633146 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4645319 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3663671 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4648389 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4646414 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4638272 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL499915 | CARBENOXOLONE | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4638268 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL4649416 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4632806 | — | IC50 | = | 1207.0 | nM | 5.92 |
| CHEMBL4647977 | — | IC50 | = | 2803.0 | nM | 5.55 |