Assay Detail
Functional
CHEMBL4603844
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.98 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4646521 | — | — | 1 | 7.44 |
| CHEMBL4645988 | — | — | 1 | 6.80 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.41 |
| CHEMBL4644554 | — | — | 1 | 6.00 |
| CHEMBL4648258 | — | — | 1 | 5.92 |
| CHEMBL9941 | — | — | 1 | 5.82 |
| CHEMBL4634290 | — | — | 1 | 5.80 |
| CHEMBL4646906 | — | — | 1 | 5.75 |
| CHEMBL4645339 | — | — | 1 | 5.68 |
| CHEMBL4642386 | — | — | 1 | 5.48 |
| CHEMBL4648447 | — | — | 1 | 4.68 |
| CHEMBL441669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4646521 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4645988 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4644554 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4648258 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL9941 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4634290 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4646906 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4645339 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4642386 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4648447 | — | IC50 | = | 21030.0 | nM | 4.68 |
| CHEMBL441669 | — | IC50 | > | 50000.0 | nM | - |