Assay Detail
Binding
CHEMBL4604199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental SAH hydrolase expressed in Escherichia coli JM109 using SAH as substrate preincubated for 10 mins followed by SAH addition and measured after 20 mins by DNTB reagent-based spectrophotometric method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of 6'-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.08 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4638533 | — | — | 1 | 6.44 |
| CHEMBL4635734 | — | — | 1 | 6.43 |
| CHEMBL2115462 | — | — | 1 | 6.43 |
| CHEMBL4544781 | — | — | 1 | 5.97 |
| CHEMBL4644901 | — | — | 1 | 5.69 |
| CHEMBL4637324 | — | — | 1 | 5.52 |
| CHEMBL4640283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4638533 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4635734 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2115462 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4544781 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4644901 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4637324 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4640283 | — | IC50 | > | 100000.0 | nM | - |