Assay Detail
Functional
CHEMBL4604200
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Antiviral activity against CHIKV LS3 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect pretreated with compound followed by viral infection and measured at 96 hrs post-infection by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chikungunya virus |
| Cell Type | Vero C1008 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 6'-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.91 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4638533 | — | — | 1 | 6.92 |
| CHEMBL4544781 | — | — | 1 | 6.89 |
| CHEMBL4635734 | — | — | 1 | - |
| CHEMBL4640283 | — | — | 1 | - |
| CHEMBL4644901 | — | — | 1 | - |
| CHEMBL4637324 | — | — | 1 | - |
| CHEMBL2115462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4638533 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4544781 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4635734 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4640283 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4644901 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4637324 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2115462 | — | EC50 | > | 100000.0 | nM | - |