Assay Detail
Functional
CHEMBL4604482
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by DAPI-staining based imaging analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan <i>Orthoscuticella ventricosa</i> Collected in Australia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.98 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.52 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.15 |
| CHEMBL4647787 | — | — | 1 | 5.00 |
| CHEMBL4649836 | — | — | 1 | 4.92 |
| CHEMBL4640329 | — | — | 1 | 4.85 |
| CHEMBL441986 | — | — | 1 | 4.75 |
| CHEMBL4648910 | — | — | 1 | 4.68 |
| CHEMBL4639278 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4647787 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4649836 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4640329 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL441986 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4648910 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4639278 | — | IC50 | > | 40000.0 | nM | - |