Assay Detail
Binding
CHEMBL4604546
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Inhibition of human integrin alphavbeta3 (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.03 | 8.10 |
| Kd | 1 | 6.92 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78760 | — | — | 1 | 8.10 |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | 7.96 |
| CHEMBL1174 | EPTIFIBATIDE | 4.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78760 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL916 | TIROFIBAN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1174 | EPTIFIBATIDE | Kd | = | 120.0 | nM | 6.92 |