Assay Detail
Binding
CHEMBL4604547
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Inhibition of human integrin alphaL beta2 assessed as reduction in integrin alphaL beta2/ICAM1 protein-protein interaction by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.54 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634420 | — | — | 1 | 7.30 |
| CHEMBL4647684 | — | — | 1 | 6.70 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634420 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4647684 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 2400.0 | nM | 5.62 |