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Assay Detail

CHEMBL4604548

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human lymphocyte integrin alphaL beta2 (Cys125 to Gly311residues) expressed in Escherichia coli XL-1B cells by isothermal titration calorimetry
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Integrin alpha-L/beta-2 (LFA-1) (CHEMBL2364172)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations.
Zheng Y, Leftheris K.
J Med Chem (2020) 63 : 5675 -5696
PubMed 31999923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 7.74 7.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1233907 1 7.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1233907 Kd = 18.3 nM 7.74