Assay Detail
Functional
CHEMBL4604854
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite growth incubated for 72 hrs by DAPI staining based fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Meroisoprenoid, Heptenolides, and <i>C</i>-Benzylated Flavonoids from <i>Sphaerocoryne gracilis</i> ssp. <i>gracilis</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.22 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 9.82 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.36 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 8.12 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.35 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.34 |
| CHEMBL4636742 | — | — | 1 | 5.39 |
| CHEMBL4633269 | — | — | 1 | 5.17 |
| CHEMBL1835968 | DICHAMANETIN | — | 1 | 5.17 |
| CHEMBL4636833 | — | — | 1 | - |
| CHEMBL4647824 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4636742 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4633269 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1835968 | DICHAMANETIN | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4636833 | — | IC50 | - | — | - | |
| CHEMBL4647824 | — | IC50 | - | — | - |