Assay Detail
Binding
CHEMBL4605390
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6-tagged Plasmodium vivax DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assay
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium vivax |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 71 | 7.18 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4643360 | — | — | 1 | 8.17 |
| CHEMBL4639806 | — | — | 1 | 8.12 |
| CHEMBL4636879 | — | — | 1 | 8.03 |
| CHEMBL4644619 | — | — | 1 | 7.85 |
| CHEMBL4633246 | — | — | 1 | 7.85 |
| CHEMBL4642145 | — | — | 1 | 7.85 |
| CHEMBL4635646 | — | — | 1 | 7.82 |
| CHEMBL4636553 | — | — | 1 | 7.75 |
| CHEMBL4634454 | — | — | 1 | 7.75 |
| CHEMBL4645475 | — | — | 1 | 7.72 |
| CHEMBL4639663 | — | — | 1 | 7.72 |
| CHEMBL4646919 | — | — | 1 | 7.68 |
| CHEMBL4643370 | — | — | 1 | 7.66 |
| CHEMBL4639907 | — | — | 1 | 7.62 |
| CHEMBL4638564 | — | — | 1 | 7.51 |
| CHEMBL4639489 | — | — | 1 | 7.44 |
| CHEMBL4645764 | — | — | 1 | 7.44 |
| CHEMBL4644974 | — | — | 1 | 7.42 |
| CHEMBL4646226 | — | — | 1 | 7.40 |
| CHEMBL4635012 | — | — | 1 | 7.39 |
| CHEMBL600689 | — | — | 1 | 7.35 |
| CHEMBL4643327 | — | — | 1 | 7.29 |
| CHEMBL4649039 | — | — | 1 | 7.26 |
| CHEMBL4646287 | — | — | 1 | 7.23 |
| CHEMBL4633770 | — | — | 1 | 7.23 |
| CHEMBL4633356 | — | — | 1 | 7.22 |
| CHEMBL4641948 | — | — | 1 | 7.19 |
| CHEMBL4646801 | — | — | 1 | 7.16 |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 7.14 |
| CHEMBL4642065 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4643360 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4639806 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4636879 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4644619 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4633246 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4642145 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4635646 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4636553 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4634454 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4645475 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4639663 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4646919 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4643370 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4639907 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4638564 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4639489 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4645764 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4644974 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4646226 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4635012 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL600689 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4643327 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4649039 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4646287 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4633770 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4633356 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4641948 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4646801 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1956285 | DSM-265 | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4642065 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4634334 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4636157 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4636244 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4634831 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4633597 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4649411 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4639576 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4641398 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4634278 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4633302 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4648611 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4632943 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4647710 | — | IC50 | - | — | - | |
| CHEMBL4636579 | — | IC50 | - | — | - | |
| CHEMBL4644257 | — | IC50 | - | — | - | |
| CHEMBL4633381 | — | IC50 | - | — | - | |
| CHEMBL4644890 | — | IC50 | - | — | - | |
| CHEMBL4636376 | — | IC50 | - | — | - | |
| CHEMBL4643434 | — | IC50 | - | — | - | |
| CHEMBL4648923 | — | IC50 | - | — | - |