Assay Detail
Functional
CHEMBL4605392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum 3D7 infected in human red blood cells after 72 hrs by SYBR Green 1 dye based fluorescence assay
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 72 | 6.81 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 8.22 |
| CHEMBL1234899 | — | — | 1 | 8.15 |
| CHEMBL4636879 | — | — | 1 | 8.04 |
| CHEMBL4639806 | — | — | 1 | 8.00 |
| CHEMBL4634454 | — | — | 1 | 7.89 |
| CHEMBL4633246 | — | — | 1 | 7.85 |
| CHEMBL4635646 | — | — | 1 | 7.80 |
| CHEMBL4643360 | — | — | 1 | 7.75 |
| CHEMBL4644619 | — | — | 1 | 7.70 |
| CHEMBL4639663 | — | — | 1 | 7.57 |
| CHEMBL4639907 | — | — | 1 | 7.55 |
| CHEMBL4636553 | — | — | 1 | 7.54 |
| CHEMBL4633770 | — | — | 1 | 7.54 |
| CHEMBL4639489 | — | — | 1 | 7.48 |
| CHEMBL4643370 | — | — | 1 | 7.44 |
| CHEMBL4649411 | — | — | 1 | 7.36 |
| CHEMBL4643327 | — | — | 1 | 7.36 |
| CHEMBL4644974 | — | — | 1 | 7.33 |
| CHEMBL4641948 | — | — | 1 | 7.29 |
| CHEMBL4638564 | — | — | 1 | 7.29 |
| CHEMBL4636157 | — | — | 1 | 7.29 |
| CHEMBL4645475 | — | — | 1 | 7.22 |
| CHEMBL4642145 | — | — | 1 | 7.21 |
| CHEMBL4635012 | — | — | 1 | 7.19 |
| CHEMBL4645764 | — | — | 1 | 7.18 |
| CHEMBL4634831 | — | — | 1 | 7.09 |
| CHEMBL4633356 | — | — | 1 | 7.00 |
| CHEMBL4646287 | — | — | 1 | 6.96 |
| CHEMBL4638098 | — | — | 1 | 6.89 |
| CHEMBL4635607 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956285 | DSM-265 | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1234899 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4636879 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4639806 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4634454 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4633246 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4635646 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4643360 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4644619 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4639663 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4639907 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4636553 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4633770 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4639489 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4643370 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4649411 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4643327 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4644974 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4641948 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4638564 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4636157 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4645475 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4642145 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4635012 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4645764 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4634831 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4633356 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4646287 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4638098 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4635607 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4633797 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL600689 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4646801 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4642065 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4634334 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4636829 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4636244 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4636376 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4646226 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4633597 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4633302 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4646919 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4649039 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4641398 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4645972 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4643434 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4634278 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4634603 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4641890 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4633381 | — | EC50 | = | 1900.0 | nM | 5.72 |