Assay Detail
Binding
CHEMBL4605528
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Inhibition of oligomycin-treated GLUT in human HT1080 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Glucose Uptake Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.65 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4643788 | — | — | 1 | 7.44 |
| CHEMBL4639095 | — | — | 1 | 7.42 |
| CHEMBL4648466 | — | — | 1 | 7.13 |
| CHEMBL4645191 | — | — | 1 | 6.96 |
| CHEMBL4641937 | — | — | 1 | 6.84 |
| CHEMBL4648818 | — | — | 1 | 6.82 |
| CHEMBL4642673 | — | — | 1 | 6.70 |
| CHEMBL4634911 | — | — | 1 | 6.59 |
| CHEMBL4634395 | — | — | 1 | 6.55 |
| CHEMBL4637469 | — | — | 1 | 6.53 |
| CHEMBL4642368 | — | — | 1 | 6.48 |
| CHEMBL4634177 | — | — | 1 | 6.46 |
| CHEMBL4642715 | — | — | 1 | 5.70 |
| CHEMBL4637224 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4643788 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4639095 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4648466 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4645191 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4641937 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4648818 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4642673 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4634911 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL4634395 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL4637469 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL4642368 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL4634177 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4642715 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4637224 | — | IC50 | = | 3474.0 | nM | 5.46 |