Assay Detail
Binding
CHEMBL4605822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TRKC (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Efficacy and Tolerability of Pyrazolo[1,5-<i>a</i>]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.08 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636995 | — | — | 1 | 6.30 |
| CHEMBL4634073 | — | — | 1 | 5.85 |
| CHEMBL4640601 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636995 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4634073 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4640601 | — | IC50 | > | 11000.0 | nM | - |