Assay Detail
ADMET
CHEMBL4605826
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Cytotoxicity against human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter Glo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | LC-2-ad |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Efficacy and Tolerability of Pyrazolo[1,5-<i>a</i>]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.61 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4643578 | — | — | 1 | 5.89 |
| CHEMBL4644274 | — | — | 1 | 5.82 |
| CHEMBL4640601 | — | — | 1 | 5.80 |
| CHEMBL4640989 | — | — | 1 | 5.57 |
| CHEMBL4642409 | — | — | 1 | 5.55 |
| CHEMBL4639022 | — | — | 1 | 5.55 |
| CHEMBL4636056 | — | — | 1 | 5.47 |
| CHEMBL4638840 | — | — | 1 | 5.26 |
| CHEMBL4636800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4643578 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4644274 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4640601 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4640989 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4642409 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4639022 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4636056 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4638840 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4636800 | — | IC50 | > | 10000.0 | nM | - |