Assay Detail
Binding
CHEMBL4605859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in human embryonic kidney cells by manual patch clamp assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Efficacy and Tolerability of Pyrazolo[1,5-<i>a</i>]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.93 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644274 | — | — | 1 | 6.30 |
| CHEMBL4636056 | — | — | 1 | 5.55 |
| CHEMBL4643578 | — | — | 1 | - |
| CHEMBL4639022 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644274 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4636056 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4643578 | — | IC50 | - | — | - | |
| CHEMBL4639022 | — | IC50 | - | — | - |