Assay Detail
Binding
CHEMBL4605919
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Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.15 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639893 | — | — | 1 | 8.40 |
| CHEMBL4640681 | — | — | 1 | 8.30 |
| CHEMBL4648504 | — | — | 1 | 8.15 |
| CHEMBL4633222 | — | — | 1 | 7.92 |
| CHEMBL4646013 | — | — | 1 | 7.89 |
| CHEMBL4632493 | — | — | 1 | 7.85 |
| CHEMBL4633123 | — | — | 1 | 7.85 |
| CHEMBL4440992 | — | — | 1 | 7.85 |
| CHEMBL2326089 | — | — | 1 | 7.75 |
| CHEMBL4647529 | — | — | 1 | 7.70 |
| CHEMBL4648095 | — | — | 1 | 7.66 |
| CHEMBL4632821 | — | — | 1 | 7.64 |
| CHEMBL4639162 | — | — | 1 | 7.54 |
| CHEMBL4639122 | — | — | 1 | 7.48 |
| CHEMBL4639443 | — | — | 1 | 7.43 |
| CHEMBL4632863 | — | — | 1 | 7.37 |
| CHEMBL4636445 | — | — | 1 | 7.37 |
| CHEMBL4646697 | — | — | 1 | 7.28 |
| CHEMBL4637242 | — | — | 1 | 7.09 |
| CHEMBL4639175 | — | — | 1 | 7.08 |
| CHEMBL4647364 | — | — | 1 | 6.97 |
| CHEMBL4553794 | — | — | 1 | 6.95 |
| CHEMBL4643311 | — | — | 1 | 6.80 |
| CHEMBL4637540 | — | — | 1 | 6.75 |
| CHEMBL4647269 | — | — | 1 | 6.75 |
| CHEMBL4645115 | — | — | 1 | 6.66 |
| CHEMBL4643670 | — | — | 1 | 6.62 |
| CHEMBL4643616 | — | — | 1 | 6.60 |
| CHEMBL4638362 | — | — | 1 | 6.59 |
| CHEMBL1812661 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639893 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4640681 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4648504 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4633222 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4646013 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4632493 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4633123 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4440992 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2326089 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4647529 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4648095 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4632821 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4639162 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4639122 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4639443 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4632863 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4636445 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4646697 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4637242 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4639175 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4647364 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4553794 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4643311 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4637540 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4647269 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4645115 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4643670 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL4643616 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4638362 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL1812661 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL4638209 | — | IC50 | = | 522.0 | nM | 6.28 |
| CHEMBL4636066 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL4647330 | — | IC50 | = | 1212.0 | nM | 5.92 |
| CHEMBL4642576 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL4635957 | — | IC50 | = | 5273.0 | nM | 5.28 |