Assay Detail
Binding
CHEMBL4605958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.61 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635160 | — | — | 1 | 6.40 |
| CHEMBL4638458 | — | — | 1 | 5.57 |
| CHEMBL4647217 | — | — | 1 | 5.38 |
| CHEMBL4634092 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635160 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4638458 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4647217 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4634092 | — | IC50 | = | 8000.0 | nM | 5.10 |