Assay Detail
Binding
CHEMBL4606150
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Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluorescence based assay
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 7.63 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642874 | — | — | 1 | 9.14 |
| CHEMBL4632569 | — | — | 1 | 9.03 |
| CHEMBL4634521 | — | — | 1 | 8.70 |
| CHEMBL4639966 | — | — | 1 | 8.70 |
| CHEMBL4640304 | — | — | 1 | 8.70 |
| CHEMBL4640415 | — | — | 1 | 8.70 |
| CHEMBL4640356 | — | — | 1 | 8.52 |
| CHEMBL4633137 | — | — | 1 | 8.52 |
| CHEMBL4636523 | — | — | 1 | 8.52 |
| CHEMBL4636734 | — | — | 1 | 8.40 |
| CHEMBL4640407 | — | — | 1 | 8.40 |
| CHEMBL4646011 | — | — | 1 | 8.40 |
| CHEMBL4640593 | — | — | 1 | 8.30 |
| CHEMBL4647467 | — | — | 1 | 8.30 |
| CHEMBL4646613 | — | — | 1 | 8.30 |
| CHEMBL4646320 | — | — | 1 | 8.22 |
| CHEMBL4646451 | — | — | 1 | 8.22 |
| CHEMBL4647859 | — | — | 1 | 8.15 |
| CHEMBL4633570 | — | — | 1 | 8.10 |
| CHEMBL4648856 | — | — | 1 | 8.10 |
| CHEMBL4646610 | — | — | 1 | 8.05 |
| CHEMBL4643094 | — | — | 1 | 8.05 |
| CHEMBL4644988 | — | — | 1 | 8.00 |
| CHEMBL4646807 | — | — | 1 | 8.00 |
| CHEMBL4636298 | — | — | 1 | 8.00 |
| CHEMBL4646862 | — | — | 1 | 7.96 |
| CHEMBL4633692 | — | — | 1 | 7.92 |
| CHEMBL4646185 | — | — | 1 | 7.92 |
| CHEMBL4639928 | — | — | 1 | 7.92 |
| CHEMBL4634357 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642874 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4632569 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL4639966 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4640304 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4640415 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4634521 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4640356 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4633137 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4636523 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4636734 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4640407 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4646011 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4646613 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4647467 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4640593 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4646320 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4646451 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4647859 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4633570 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4648856 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4646610 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4643094 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4644988 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4646807 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4636298 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4646862 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4646185 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4639928 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4633692 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4634357 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4643555 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4646512 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4633594 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4642831 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4633012 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL191091 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4639790 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4645602 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4633750 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4634503 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4632914 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4642153 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4648635 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4644709 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4633075 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4647881 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL356824 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4646653 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4643485 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL190727 | — | IC50 | = | 218.0 | nM | 6.66 |