Assay Detail
Functional
CHEMBL4606182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MM96L cells assessed as increase in intracellular caspase 3/7 release incubated for 72 hrs by Caspase-Glo 3/7 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM96L |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.64 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642874 | — | — | 1 | 7.22 |
| CHEMBL191091 | — | — | 1 | 6.05 |
| CHEMBL4640415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642874 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL191091 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4640415 | — | EC50 | < | 100000.0 | nM | - |