Assay Detail
Binding
CHEMBL4606193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 in human MM96L cells assessed as activation of histone H4 acetylation at Lys5, Lys8, Lys12 and Lys16 residues by Western blot analysis
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MM96L |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.22 | 6.70 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642874 | — | — | 2 | 6.70 |
| CHEMBL4634521 | — | — | 2 | 6.22 |
| CHEMBL191091 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642874 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4634521 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL191091 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4634521 | — | Inhibition | - | % | - | |
| CHEMBL4642874 | — | Inhibition | - | % | - |