Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4606197

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-seizure activity in Zebrafish
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Danio rerio
Confidence 1 — Organism
Curated By Autocuration

Target

Danio rerio (CHEMBL613963)
Type ORGANISM
Organism Danio rerio

Publication

Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures.
Li X, Himes RA, Prosser LC, Christie CF, Watt E, Edwards SF, Metcalf CS, West PJ, Wilcox KS, Chan SSL, Chou CJ.
J Med Chem (2020) 63 : 5865 -5878
PubMed 32390424 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 5.11 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL590 MENADIONE 4.0 1 5.52
CHEMBL2334460 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL590 MENADIONE EC50 = 3000.0 nM 5.52
CHEMBL2334460 EC50 = 20000.0 nM 4.70