Assay Detail
ADMET
CHEMBL4606264
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 72 | 5.11 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4643264 | — | — | 1 | 6.71 |
| CHEMBL4641129 | — | — | 1 | 6.26 |
| CHEMBL4640206 | — | — | 1 | 6.12 |
| CHEMBL4639615 | — | — | 1 | 6.11 |
| CHEMBL4646969 | — | — | 1 | 6.10 |
| CHEMBL4640162 | — | — | 1 | 5.52 |
| CHEMBL4642651 | — | — | 1 | 5.52 |
| CHEMBL4634684 | — | — | 1 | 5.24 |
| CHEMBL4642934 | — | — | 1 | 5.03 |
| CHEMBL4642666 | — | — | 1 | 4.98 |
| CHEMBL4637212 | — | — | 1 | 4.96 |
| CHEMBL4646921 | — | — | 1 | 4.83 |
| CHEMBL4644159 | — | — | 1 | 4.81 |
| CHEMBL4649093 | — | — | 1 | 4.73 |
| CHEMBL4635811 | — | — | 1 | 4.65 |
| CHEMBL4649720 | — | — | 1 | 4.65 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 4.63 |
| CHEMBL4642508 | — | — | 1 | 4.59 |
| CHEMBL4643150 | — | — | 1 | 4.59 |
| CHEMBL4646227 | — | — | 1 | 4.56 |
| CHEMBL4639326 | — | — | 1 | 4.55 |
| CHEMBL4637990 | — | — | 1 | 4.51 |
| CHEMBL4639323 | — | — | 1 | 4.50 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.42 |
| CHEMBL4632610 | — | — | 1 | - |
| CHEMBL4648678 | — | — | 1 | - |
| CHEMBL4637000 | — | — | 1 | - |
| CHEMBL4640747 | — | — | 1 | - |
| CHEMBL4644390 | — | — | 1 | - |
| CHEMBL4641165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4643264 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL4641129 | — | IC50 | = | 548.0 | nM | 6.26 |
| CHEMBL4640206 | — | IC50 | = | 755.0 | nM | 6.12 |
| CHEMBL4639615 | — | IC50 | = | 772.0 | nM | 6.11 |
| CHEMBL4646969 | — | IC50 | = | 798.0 | nM | 6.10 |
| CHEMBL4640162 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4642651 | — | IC50 | = | 3036.0 | nM | 5.52 |
| CHEMBL4634684 | — | IC50 | = | 5779.0 | nM | 5.24 |
| CHEMBL4642934 | — | IC50 | = | 9432.0 | nM | 5.03 |
| CHEMBL4642666 | — | IC50 | = | 10365.0 | nM | 4.98 |
| CHEMBL4637212 | — | IC50 | = | 10992.0 | nM | 4.96 |
| CHEMBL4646921 | — | IC50 | = | 14838.0 | nM | 4.83 |
| CHEMBL4644159 | — | IC50 | = | 15617.0 | nM | 4.81 |
| CHEMBL4649093 | — | IC50 | = | 18673.0 | nM | 4.73 |
| CHEMBL4649720 | — | IC50 | = | 22462.0 | nM | 4.65 |
| CHEMBL4635811 | — | IC50 | = | 22223.0 | nM | 4.65 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 23160.0 | nM | 4.63 |
| CHEMBL4643150 | — | IC50 | = | 25614.0 | nM | 4.59 |
| CHEMBL4642508 | — | IC50 | = | 25903.0 | nM | 4.59 |
| CHEMBL4646227 | — | IC50 | = | 27266.0 | nM | 4.56 |
| CHEMBL4639326 | — | IC50 | = | 27908.0 | nM | 4.55 |
| CHEMBL4637990 | — | IC50 | = | 30722.0 | nM | 4.51 |
| CHEMBL4639323 | — | IC50 | = | 31972.0 | nM | 4.50 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 37577.0 | nM | 4.42 |
| CHEMBL4642414 | — | IC50 | > | 24672.0 | nM | - |
| CHEMBL4635459 | — | IC50 | > | 34418.0 | nM | - |
| CHEMBL4638979 | — | IC50 | > | 24672.0 | nM | - |
| CHEMBL4643592 | — | IC50 | > | 24711.0 | nM | - |
| CHEMBL4636890 | — | IC50 | > | 22232.0 | nM | - |
| CHEMBL4632695 | — | IC50 | > | 23052.0 | nM | - |
| CHEMBL4640720 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4647566 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4649202 | — | IC50 | > | 23735.0 | nM | - |
| CHEMBL4634780 | — | IC50 | > | 24672.0 | nM | - |
| CHEMBL4643282 | — | IC50 | > | 26898.0 | nM | - |
| CHEMBL4634377 | — | IC50 | > | 34767.0 | nM | - |
| CHEMBL4648872 | — | IC50 | > | 34418.0 | nM | - |
| CHEMBL4641685 | — | IC50 | > | 23735.0 | nM | - |
| CHEMBL4640006 | — | IC50 | > | 36216.0 | nM | - |
| CHEMBL4645747 | — | IC50 | > | 29644.0 | nM | - |
| CHEMBL4638115 | — | IC50 | > | 34846.0 | nM | - |
| CHEMBL4632642 | — | IC50 | > | 34846.0 | nM | - |
| CHEMBL4632816 | — | IC50 | > | 23735.0 | nM | - |
| CHEMBL4635723 | — | IC50 | > | 34495.0 | nM | - |
| CHEMBL4641165 | — | IC50 | > | 34495.0 | nM | - |
| CHEMBL4644390 | — | IC50 | > | 36216.0 | nM | - |
| CHEMBL4640747 | — | IC50 | > | 37289.0 | nM | - |
| CHEMBL4637000 | — | IC50 | > | 37289.0 | nM | - |
| CHEMBL4648678 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4632610 | — | IC50 | > | 36216.0 | nM | - |