Assay Detail
Functional
CHEMBL4606273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA 676m1cl1 sporozoites infected in human HepG2A16 cells measured after 45 hrs by luciferase-luciferin based reporter gene assay
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 7.64 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642414 | — | — | 1 | 9.92 |
| CHEMBL4638979 | — | — | 1 | 9.70 |
| CHEMBL4644361 | — | — | 1 | 9.39 |
| CHEMBL4640206 | — | — | 1 | 9.35 |
| CHEMBL4643264 | — | — | 1 | 9.34 |
| CHEMBL4640537 | — | — | 1 | 9.30 |
| CHEMBL4641685 | — | — | 1 | 9.29 |
| CHEMBL4646921 | — | — | 1 | 9.22 |
| CHEMBL4632816 | — | — | 1 | 9.19 |
| CHEMBL4649202 | — | — | 1 | 9.15 |
| CHEMBL4638013 | — | — | 1 | 8.82 |
| CHEMBL4639249 | — | — | 1 | 8.80 |
| CHEMBL4639615 | — | — | 1 | 8.77 |
| CHEMBL4634377 | — | — | 1 | 8.66 |
| CHEMBL4634684 | — | — | 1 | 8.62 |
| CHEMBL4639326 | — | — | 1 | 8.36 |
| CHEMBL4647043 | — | — | 1 | 8.35 |
| CHEMBL4640162 | — | — | 1 | 8.33 |
| CHEMBL4641224 | — | — | 1 | 8.25 |
| CHEMBL4637212 | — | — | 1 | 8.23 |
| CHEMBL4649093 | — | — | 1 | 8.23 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.19 |
| CHEMBL4642666 | — | — | 1 | 8.17 |
| CHEMBL4632424 | — | — | 1 | 8.13 |
| CHEMBL4649060 | — | — | 1 | 8.13 |
| CHEMBL4644159 | — | — | 1 | 8.12 |
| CHEMBL4645747 | — | — | 1 | 8.10 |
| CHEMBL4634780 | — | — | 1 | 8.09 |
| CHEMBL4641129 | — | — | 1 | 7.85 |
| CHEMBL4639240 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642414 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4638979 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4644361 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL4640206 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL4643264 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL4640537 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4641685 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4646921 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4632816 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL4649202 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4638013 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4639249 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4639615 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4634377 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4634684 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4639326 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4647043 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4640162 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4641224 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4637212 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4649093 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4642666 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4632424 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4649060 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4644159 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4645747 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4634780 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4641129 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4639240 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4643592 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4643150 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4643282 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4646969 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4642934 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4648872 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4634180 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4637990 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4635811 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4642508 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4639209 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4635459 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4648905 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4640006 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4636824 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4637090 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4644082 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4642651 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4632642 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4638186 | — | IC50 | = | 109.0 | nM | 6.96 |