Assay Detail
Functional
CHEMBL4606282
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Antimalarial activity against Plasmodium falciparum clinical isolates measured after 72 hrs by SYBR green dye based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.45 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.57 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 8.85 |
| CHEMBL4634377 | — | — | 1 | 8.41 |
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 8.38 |
| CHEMBL4639326 | — | — | 1 | 8.27 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 8.23 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4634377 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4639326 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 34.0 | nM | 7.47 |