Assay Detail
Functional
CHEMBL4606355
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Antileishmanial activity against Leishmania infantum MON-1 intracellular amastigotes infected in Swiss mouse BMDM measured after 48 hrs by Giemsa staining based optical microscopic analysis
11
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
O-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.32 | 6.36 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577299 | — | — | 1 | 6.36 |
| CHEMBL4648210 | — | — | 1 | 5.98 |
| CHEMBL935 | — | — | 1 | 5.82 |
| CHEMBL4640366 | — | — | 2 | 5.49 |
| CHEMBL4634691 | — | — | 1 | 5.43 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.20 |
| CHEMBL4636514 | — | — | 1 | 4.16 |
| CHEMBL4644349 | — | — | 1 | 4.13 |
| CHEMBL239129 | MEGLUMINE ANTIMONATE | 3.0 | 1 | - |
| CHEMBL4645118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577299 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4648210 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL935 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4640366 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4634691 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4636514 | — | IC50 | = | 69100.0 | nM | 4.16 |
| CHEMBL4644349 | — | IC50 | = | 74900.0 | nM | 4.13 |
| CHEMBL239129 | MEGLUMINE ANTIMONATE | IC50 | = | 144400.0 | nM | - |
| CHEMBL4645118 | — | IC50 | - | — | - | |
| CHEMBL4640366 | — | Activity | - | — | - |