Assay Detail
Binding
CHEMBL4606403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in HEK293 cells measured after 30 mins by FluxOR dye based FLIPR TETRA assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
O-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.46 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.94 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 5.92 |
| CHEMBL1008 | BEPRIDIL | 4.0 | 1 | 5.85 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 5.58 |
| CHEMBL4640366 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL17157 | TERFENADINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1008 | BEPRIDIL | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4640366 | — | IC50 | = | 96220.0 | nM | 4.02 |