Assay Detail
Binding
CHEMBL4606495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Toxoplasma gondii full-length wild-type C-terminal His-tagged CDPK1 expressed in Escherichia coli BL21(DE3)V2RpAcYc-LIC+LamP using syntide-2 peptide as substrate incubated for 20 to 40 mins by ELISA
92
Total Activities
92
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 92 | 7.43 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635651 | — | — | 1 | 8.21 |
| CHEMBL4638526 | — | — | 1 | 8.20 |
| CHEMBL4646408 | — | — | 1 | 8.18 |
| CHEMBL4644826 | — | — | 1 | 8.14 |
| CHEMBL4639143 | — | — | 1 | 8.08 |
| CHEMBL4637661 | — | — | 1 | 8.07 |
| CHEMBL4642015 | — | — | 1 | 8.05 |
| CHEMBL4639324 | — | — | 1 | 8.01 |
| CHEMBL4633707 | — | — | 1 | 8.01 |
| CHEMBL4642003 | — | — | 1 | 8.00 |
| CHEMBL4087915 | — | — | 1 | 8.00 |
| CHEMBL4646297 | — | — | 1 | 8.00 |
| CHEMBL4645471 | — | — | 1 | 8.00 |
| CHEMBL4634322 | — | — | 1 | 8.00 |
| CHEMBL4635640 | — | — | 1 | 7.96 |
| CHEMBL4639820 | — | — | 1 | 7.96 |
| CHEMBL4633197 | — | — | 1 | 7.92 |
| CHEMBL4635893 | — | — | 1 | 7.92 |
| CHEMBL4635943 | — | — | 1 | 7.85 |
| CHEMBL4640453 | — | — | 1 | 7.85 |
| CHEMBL4635518 | — | — | 1 | 7.85 |
| CHEMBL4094646 | — | — | 1 | 7.85 |
| CHEMBL4648757 | — | — | 1 | 7.85 |
| CHEMBL4642579 | — | — | 1 | 7.83 |
| CHEMBL4632714 | — | — | 1 | 7.82 |
| CHEMBL4639535 | — | — | 1 | 7.82 |
| CHEMBL4640539 | — | — | 1 | 7.82 |
| CHEMBL4634455 | — | — | 1 | 7.80 |
| CHEMBL4646842 | — | — | 1 | 7.80 |
| CHEMBL4638200 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635651 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4638526 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4646408 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4644826 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4639143 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4637661 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4642015 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4639324 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4633707 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4642003 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4087915 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4646297 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4645471 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4634322 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4639820 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4635640 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4633197 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4635893 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4635943 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4640453 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4635518 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4094646 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4648757 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4642579 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL4640539 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4639535 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4632714 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4634455 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4646842 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4638200 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4642751 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4632874 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4632768 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4634018 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4642332 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4634037 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4643794 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4636934 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4635750 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4636058 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4641821 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4641131 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4645733 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4635287 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4637312 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4646062 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4643982 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4637560 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4641225 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4649549 | — | IC50 | = | 30.0 | nM | 7.52 |