Assay Detail
Binding
CHEMBL4606698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DNMT1 expressed in baculovirus infected insect cells using CpG site containing internally quenched hairpin oligonucleotide DNA substrate and SAM incubated for 30 mins by kinetic fluorogenic assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA (cytosine-5)-methyltransferase 1 (CHEMBL1993) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Guided Identification of DNMT3B Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.56 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4640870 | — | — | 1 | 4.57 |
| CHEMBL4649221 | — | — | 1 | 4.54 |
| CHEMBL4641323 | — | — | 1 | - |
| CHEMBL4644275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4640870 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4649221 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4641323 | — | IC50 | - | — | - | |
| CHEMBL4644275 | — | IC50 | - | — | - |