Assay Detail
Binding
CHEMBL4606704
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Inhibition of human CA12 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.85 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4643924 | — | — | 1 | 8.51 |
| CHEMBL4450272 | — | — | 1 | 8.42 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL4453778 | — | — | 1 | 8.25 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4636788 | — | — | 1 | 8.21 |
| CHEMBL4643162 | — | — | 1 | 8.20 |
| CHEMBL4646283 | — | — | 1 | 8.16 |
| CHEMBL4646670 | — | — | 1 | 8.11 |
| CHEMBL4642319 | — | — | 1 | 8.09 |
| CHEMBL4643664 | — | — | 1 | 8.09 |
| CHEMBL4643115 | — | — | 1 | 8.07 |
| CHEMBL4643700 | — | — | 1 | 8.07 |
| CHEMBL4634428 | — | — | 1 | 7.58 |
| CHEMBL4640698 | — | — | 1 | 7.58 |
| CHEMBL4634837 | — | — | 1 | 7.56 |
| CHEMBL4649709 | — | — | 1 | 7.54 |
| CHEMBL4645839 | — | — | 1 | 7.43 |
| CHEMBL4638496 | — | — | 1 | 7.40 |
| CHEMBL4644997 | — | — | 1 | 7.31 |
| CHEMBL4632436 | — | — | 1 | 7.20 |
| CHEMBL4633355 | — | — | 1 | 7.17 |
| CHEMBL4647300 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4643924 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL4450272 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL4453778 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4636788 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL4643162 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4646283 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL4646670 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4642319 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4643664 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4643115 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4643700 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4634428 | — | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL4640698 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL4634837 | — | Ki | = | 27.4 | nM | 7.56 |
| CHEMBL4649709 | — | Ki | = | 29.1 | nM | 7.54 |
| CHEMBL4645839 | — | Ki | = | 37.4 | nM | 7.43 |
| CHEMBL4638496 | — | Ki | = | 39.6 | nM | 7.40 |
| CHEMBL4644997 | — | Ki | = | 48.7 | nM | 7.31 |
| CHEMBL4632436 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL4633355 | — | Ki | = | 66.9 | nM | 7.17 |
| CHEMBL4647300 | — | Ki | = | 86.3 | nM | 7.06 |