Assay Detail
Binding
CHEMBL4610164
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Inhibition of xanthine oxidase (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological urate-lowering approaches in chronic kidney disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.87 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1164729 | FEBUXOSTAT | 4.0 | 1 | 9.22 |
| CHEMBL1078685 | TOPIROXOSTAT | 2.0 | 1 | 8.24 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1164729 | FEBUXOSTAT | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1078685 | TOPIROXOSTAT | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL1467 | ALLOPURINOL | Ki | = | 700.0 | nM | 6.16 |