Assay Detail

CHEMBL4610168

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Binding

Inhibition of OAT4 (unknown origin)

ChEMBL ↗

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Target

Solute carrier family 22 member 11 (CHEMBL2073677) ↗

Open DB target context

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Solute carrier family 22 member 11 (CHEMBL2073677) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Solute carrier family 22 member 11

CHEMBL2073677

Anchored from Assay target.

Protein identity Solute carrier family 22 member 11

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Solute carrier family 22 member 11 (CHEMBL2073677) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Pharmacological urate-lowering approaches in chronic kidney disease.

Li X, Liu J, Ma L, Fu P.
Eur J Med Chem (2019) 166 : 186 -196
PubMed 30769179 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.70	5.14

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2105720	LESINURAD	4.0	1	5.14
CHEMBL897	PROBENECID	4.0	1	4.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2105720	LESINURAD	IC50	=	7300.0	nM	5.14
CHEMBL897	PROBENECID	IC50	=	54900.0	nM	4.26