Assay Detail
Functional
CHEMBL4610252
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Antiviral activity against HCV genotype 1b Con1 expressing wild type NS5B infected in human HuH7 replicon cells assessed as inhibition of viral replication after 4 days by luciferase reporter gene based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.52 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4649858 | — | — | 1 | 7.82 |
| CHEMBL4636436 | — | — | 1 | 7.52 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4649858 | — | EC50 | = | 15.2 | nM | 7.82 |
| CHEMBL4636436 | — | EC50 | = | 30.4 | nM | 7.52 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 62.0 | nM | 7.21 |