Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4610604

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Rational design, synthesis and biological profiling of new KDM4C inhibitors.
Letfus V, Jelić D, Bokulić A, Petrinić Grba A, Koštrun S.
Bioorg Med Chem (2020) 28 : 115128 -115128
PubMed 31784197 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.74 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4648732 1 6.10
CHEMBL1517074 1 6.10
CHEMBL1438218 1 6.09
CHEMBL1527391 1 6.06
CHEMBL4649004 1 5.96
CHEMBL4639254 1 5.92
CHEMBL1316847 1 5.75
CHEMBL4646339 1 5.68
CHEMBL4640783 1 5.35
CHEMBL578512 1 5.35
CHEMBL1394266 1 5.29
CHEMBL4640696 1 5.25
CHEMBL4636575 1 -
CHEMBL4646564 1 -
CHEMBL4640130 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4648732 IC50 = 800.0 nM 6.10
CHEMBL1517074 IC50 = 800.0 nM 6.10
CHEMBL1438218 IC50 = 820.0 nM 6.09
CHEMBL1527391 IC50 = 870.0 nM 6.06
CHEMBL4649004 IC50 = 1100.0 nM 5.96
CHEMBL4639254 IC50 = 1200.0 nM 5.92
CHEMBL1316847 IC50 = 1800.0 nM 5.75
CHEMBL4646339 IC50 = 2100.0 nM 5.68
CHEMBL4640783 IC50 = 4500.0 nM 5.35
CHEMBL578512 IC50 = 4500.0 nM 5.35
CHEMBL1394266 IC50 = 5100.0 nM 5.29
CHEMBL4640696 IC50 = 5600.0 nM 5.25
CHEMBL4636575 IC50 > 25000.0 nM -
CHEMBL4646564 IC50 > 25000.0 nM -
CHEMBL4640130 IC50 > 25000.0 nM -