Assay Detail
Functional
CHEMBL4610642
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Antiproliferative activity against human T98 cells assessed as reduction in cell viability incubated for 5 days by Prestoblue reagent based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T98 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.14 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797933 | — | — | 1 | 8.00 |
| CHEMBL3800481 | — | — | 1 | 7.00 |
| CHEMBL3797590 | — | — | 1 | 7.00 |
| CHEMBL3800138 | — | — | 1 | 7.00 |
| CHEMBL3797834 | — | — | 1 | 7.00 |
| CHEMBL4641170 | — | — | 1 | 7.00 |
| CHEMBL4644635 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797933 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3800481 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3797590 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3800138 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3797834 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4641170 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4644635 | — | EC50 | = | 100.0 | nM | 7.00 |