Assay Detail
Binding
CHEMBL4610746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive binding affinity to GST-tagged human PPARdelta LBD incubated for 1 to 6 hrs by TR-FRET assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.70 | 8.85 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38943 | GW501516 | 2.0 | 1 | 8.85 |
| CHEMBL4079448 | — | — | 2 | 7.84 |
| CHEMBL200732 | — | — | 1 | 7.39 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38943 | GW501516 | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4079448 | — | EC50 | = | 14.4 | nM | 7.84 |
| CHEMBL200732 | — | EC50 | = | 41.1 | nM | 7.39 |
| CHEMBL431733 | NAMODENOSON | EC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4079448 | — | Activity | - | — | - |