Assay Detail
Binding
CHEMBL4610751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist at PPARdelta LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 cotreated with PPARdelta agonist GW501516 by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.05 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592652 | — | — | 1 | 5.40 |
| CHEMBL4079448 | — | — | 1 | 5.28 |
| CHEMBL200732 | — | — | 1 | 4.97 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592652 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4079448 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL200732 | — | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL431733 | NAMODENOSON | EC50 | = | 29800.0 | nM | 4.53 |