Assay Detail
Binding
CHEMBL4610865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | C3H 10T1/2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 8.24 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644674 | — | — | 1 | 9.10 |
| CHEMBL4639432 | — | — | 1 | 9.05 |
| CHEMBL4643226 | — | — | 1 | 9.00 |
| CHEMBL4632769 | — | — | 1 | 9.00 |
| CHEMBL4648026 | — | — | 1 | 8.96 |
| CHEMBL4637249 | — | — | 1 | 8.77 |
| CHEMBL4644175 | — | — | 1 | 8.64 |
| CHEMBL4637222 | — | — | 1 | 8.59 |
| CHEMBL4640840 | — | — | 1 | 8.54 |
| CHEMBL4636369 | — | — | 1 | 8.54 |
| CHEMBL4637218 | — | — | 1 | 8.51 |
| CHEMBL4647379 | — | — | 1 | 8.51 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 8.33 |
| CHEMBL4641050 | — | — | 1 | 8.17 |
| CHEMBL2059867 | — | — | 1 | 8.17 |
| CHEMBL4642917 | — | — | 1 | 8.12 |
| CHEMBL2059865 | — | — | 1 | 7.89 |
| CHEMBL4638476 | — | — | 1 | 7.89 |
| CHEMBL4636326 | — | — | 1 | 7.77 |
| CHEMBL2059861 | — | — | 1 | 7.75 |
| CHEMBL2059868 | — | — | 1 | 7.68 |
| CHEMBL4636352 | — | — | 1 | 7.64 |
| CHEMBL2059869 | — | — | 1 | 7.57 |
| CHEMBL4637915 | — | — | 1 | 7.52 |
| CHEMBL2059860 | — | — | 1 | 7.41 |
| CHEMBL2059866 | — | — | 1 | 7.05 |
| CHEMBL4646211 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644674 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4639432 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4643226 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4632769 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4648026 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4637249 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4644175 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4637222 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4640840 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4636369 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4637218 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4647379 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL473417 | VISMODEGIB | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4641050 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2059867 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4642917 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL2059865 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4638476 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4636326 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2059861 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2059868 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4636352 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2059869 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4637915 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2059860 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2059866 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4646211 | — | EC50 | < | 1.5 | nM | - |